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Such efforts may advance along three critical dimensions: elucidating the precise underlying mechanisms, characterizing the dynamic behavior of biomarkers, and addressing patient heterogeneity

(Yang et al

Pedersen et al

Konings, H

But consider this: if your protocol involves doses that increase over weeks, a single starting concentration may eventually require drawing volumes that are either too small to measure accurately (below 0.05 mL) or too large for the injection site